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Lymphoma and Leukaemia Diagnosis

Diagnostics

State-of-the-art diagnosis of haematological malignancies includes morphology and haematopathology, immunophenotyping and immunohistochemistry, cytogenetics and molecular genetics. Samples arrive in one central specimen reception and are treated according to defined algorithms in order to avoid test duplication. Results obtained by each approach are integrated into one single overall diagnosis and presented for discussion to the multidisciplinary tumour site specific group meetings. The aim is to increase speed and precision of diagnosis and to avoid unnecessary or inappropriate treatments.

Oxford BRC translational research

The laboratory aims to be actively involved in translational research.

It provides samples for ethically approved research projects and works closely with the Oxford Biobank. It supports clinical trials and biological studies through full characterization of clinical samples and minimal residual disease monitoring. It translates and validates new technologies and it is currently developing its own focus of research into leukaemia propagating cells in B-cell chronic lymphocytic leukaemia.

5.1 AML

• Schlenk R F et al. N Engl J Med. 2008 May 1;358(18):1909-18.
  http://content.nejm.org/cgi/content/abstract/358/18/1909
• Kern W et al. Cancer. 2008 Jan 1;112(1):4-16.
  http://www3.interscience.wiley.com/cgi-bin/fulltext/116841938/HTMLSTART

5.2 CLL

• Byrd J C et al. Hematology. 2004;2004:163-183.
  http://asheducationbook.hematologylibrary.org/cgi/reprint/2004/1/163
• Oscier et al. Blood. 2002 Aug 15;100(4):1177-1184.
  http://bloodjournal.hematologylibrary.org/cgi/content/full/100/4/1177

5.3 CML

• Druker B J et al. N Engl J Med. 2006 Dec 7;355(23):2408-17.
  http://content.nejm.org/cgi/content/abstract/355/23/2408
• Baccarani et al. Blood. 2006 Sep 15;108(6):1809-20. Epub 2006 May 18. Review.
  http://bloodjournal.hematologylibrary.org/cgi/content/full/108/6/1809
• Hughes T et al. Blood. 2006 Jul 1;108(1):28-37. Epub 2006 Mar 7. Review.
  http://bloodjournal.hematologylibrary.org/cgi/content/full/108/1/28
• Hughes T. Hematology Am Soc Hematol Educ Program. 2006:211-8. Review.
  http://asheducationbook.hematologylibrary.org/cgi/content/full/2006/1/211
• Cross N et al. Leuk Res. 2008 Mar;32(3):505-6. Epub 2007 May 18. No abstract available.

5.4 ALL

5.5 NHL